Eric Lu Zhang
Assistant Professor
Department of Computer Science
Hong Kong Baptist University
Kowloon Tong, Hong Kong
ericluzhang AT comp DOT hkbu DOT edu DOT hk
Phone: (852) 3411-5880
Fax: (852) 3411-7892
Office: Room R708, Sir Run Run Shaw Building

I received B.E. in Software Engineering from the Tianjin University , Tianjin, P.R.China in July 2008, M.phil in Bioinformatics from The University of Hong Kong in Sept. 2012 and Ph.D. in Computer Science from the City University of Hong Kong in Feb. 2016. During June 2016 - Jan. 2019, I was a postdoctoral scholar at Department of Computer Science and Pathology, Stanford University, Stanford, USA and worked with Serafim Batzoglou , Arend Sidow and James Zou. I joined Hong Kong Baptist University as Assistant Professor of Computer Science in Feb. 2019, and I was a visiting student at Department of Mathmatics, UC Berkeley and worked with Stephen Smale .

For a complete list of my publications and other detailed info, please see my Google Scholar page or CV.

Openings: I am looking for talented and self-motivated PhD students, Postdocs and Research Assistant Professors who are interested in computational genomics and machine learning in genomics. Please contact me by email with your CV and research proposal.



Office Hours

4-5pm every Friday in DLB641, but please always feel free to come by. If you are a HKBU graduate or undergraduate student interested in machine learning or computational genomics, please feel free to email me about potential projects.

Selected Publications (+joint first author,*corresponding author,)

  • Debajyoti Chowdhury, Maizie (Xin) Zhou, Bailiang Li, Yuanwei Zhang, William K Cheung, Aiping Lu, Lu Zhang*. Multi-omics integration accelerates the predictive health to augment early diagnosis of common diseases. Accepted by Frontiers in Genetics, section Computational Genomics.
  • Md Selim Reza, Yunpeng Cai, Lu Zhang, Xingyu Zhang, Yanjie Wei. Computational Solutions for Microbiome and Metagenomics Sequencing Analyses. Accepted by Frontiers in Molecular Biosciences, section Molecular Diagnostics and Therapeutics
  • Zi-Hang Wen, Jeremy L. Langsam, Lu Zhang, Wenjun Shen, Xin Zhou. Bfimpute: A Bayesian factorization method to recover single-cell RNA sequencing data. BioRxiv.
  • Yichen Henry Liu, Griffin L. Grubbs, Lu Zhang, Xiaodong Fang, David L. Dill, Arend Sidow, Xin Zhou. Aquila_stLFR: diploid genome assembly based structural variant calling package for stLFR linked-read. Bioinformatics Advances 2021.
  • Jiaxing Chen, Chinwang Cheong, Liang Lan, Xin Zhou, Jiming Liu, Aiping Lyu, William K Cheung*, Lu Zhang*. DeepDRIM: a deep neural network to reconstruct cell-type-specific gene regulatory network using single-cell RNA-Seq Data. Presented on Recomb-Seq 2021 and the extended version will be published on Briefings in Bioinformatics
  • Zhenmiao Zhang, Lu Zhang*. METAMVGL: a multi-view graph-based metagenomic contig binning algorithm by integrating assembly and paired-end graphs. Invited to BMC Bioinformatics-APBC Special Issue and Accepted to APBC 2021.
  • Xin Zhou, Lu Zhang, Ziming Weng, David Dill, Arend Sidow. Aquila: diploid personal genome assembly and comprehensive variant detection based on linked reads. Nature Communications 2021.
  • Lu Zhang+*, Xiaodong Fang+, Herui Liao+, Zhenmiao Zhang, Xin Zhou, Lijuan Han, Yang Chen, Qinwei Qiu, Shuai Cheng Li. A Comprehensive Investigation of Metagenome Assembly by Linked-Read Sequencing. Microbiome 2020.
  • Lu Zhang+, Xin Zhou+, Ziming Weng, Arend Sidow. De novo diploid genome assembly for genome-wide structural variant detection. NAR Genomics and Bioinformatics 2020.
  • Lu Zhang+, Xin Zhou+, Ziming Weng, Arend Sidow. Assessment of human diploid genome assembly with 10x Linked-Reads data. GigaScience 2019.
  • JiFeng Guo+, Lu Zhang+ et al. De novo coding mutations contribute to early onset Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 2018.
  • Xin Zhou, Serafim Batzoglou, Arend Sidow, Lu Zhang*. HAPDeNovo: a haplotype-based approach for filtering and phasing de novo mutations in linked read sequencing data. BMC Genomics 2018.
  • Lu Liu+, Lu Zhang+ et al. The SNP-set based association study identifies ITGA1 as a susceptiblity gene of attention-deficit/hyperactivity disorder in Han Chinese. Translational Psychatary 2017.
  • Lu Zhang+, Cheng Qin+, Junpu Mei, et al. Identification of microRNA Targets of Capsicum spp. using MiRTrans—a trans-omics approach. Frontiers in Bioinformatics and Computational Biology 2017.
  • Lu Zhang, Xikang Feng, Yen Kaow Ng and Shuai Cheng Li. Reconstructing directed gene regulatory network by only gene expression data. Invited to BMC Genomics-BIBM Special Issue and Accepted to BIBM 2015.
  • Xueyan Li+, Dingding Fan+, Wei Zhang+, Guichun Liu+, Lu Zhang+, et al. Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies. Nature Communications 2015.
  • Jing Zhang+, Lu Zhang+, Jiaxu Hong, Dan Wu, Jianjiang Xu. Association of Common Variants in LOX with Keratoconus: A Meta-Analysis. PLOS One 2015.
  • Huashui Ai, Xiaodong Fang, Bin Yang, Zhiyong Huang, Hao Chen, Likai Mao, Feng Zhang, Lu Zhang, et al. Adaptation and possible ancient interspecies introgression in pigs identified by whole-genome sequencing. Nature Genetics 2015.
  • Lu Zhang, Jing Zhang, Jing Yang, Dingge Ying, Yu lung Lau, Wanling Yang. PriVar: a flexible toolkit for prioritizing SNV and indel from next generation sequencing data. Bioinformatics 2013.
  • Lu Zhang+, Wanling Yang+*, Dingge Ying, Stacey S. Cherny, Friedhelm Hildebrandt, Pak Chung Sham, Yu lung Lau. 2011. Homozygosity mapping on a single patient identification of homozygous regions of recent common ancestry by using population data. Human Mutation 2011.